赵小明

日期:2023-09-01来源:


fde12279b0deb9a00289dc17e7dd573e.jpg    赵小明

    职称:教授

    研究方向:   (1)昆虫生理与行为调控

                      (2)杀虫分子靶标挖掘

                      (3)绿色农药生物合成与创制

    通讯地址:zxming@sxu.edu.cn

 

赵小明,男,1984年生,安徽临泉人,博士,教授,博士生导师。现任太阳成集团生命科学学院党委委员、suncitygroup太阳集团副院长,核酸生物农药山西省重点实验室副主任,太阳成集团应用生物学研究所党支部书记、核酸生物农药科研团队功能型党支部书记;曾任应用生物学研究所所长助理,兼任中国昆虫学会昆虫生理生化与分子生物学专业委员会委员。曾获山西省“三晋英才”青年优秀人才,山西省优秀硕士学位论文指导教师,太阳成集团优秀青年教师,山西省昆虫学会优秀科技工作者,太阳成集团优秀共产党员。

2014年6月于西南大学(家蚕基因组生物学国家重点实验室)获博士学位,同年7月入职太阳成集团工作。2014年至今,以重大农业害虫为主要研究对象,开展昆虫生理与行为调控、杀虫分子靶标挖掘与绿色农药创制等研究工作。先后主持国家自然科学基金项目4项,科技部“十四五”国家重点研发计划子课题1项,中国博士后科学基金面上一等资助项目1项,山西省应用基础研究计划项目2项,山西省高等学校科技创新项目1项。作为骨干成员参加国家自然科学基金中德国际合作项目、中德交流项目和“十三五”国家重点研发计划骨干课题各1项。在PLOS Biology, Journal of Biological Chemistry, International Journal of Biological Macromolecules, Insect Biochemistry and Molecular Biology, Pesticide Biochemistry and Physiology, Insect Science等国内外著名学术期刊发表学术论文60余篇,参编中英文著作3部,授权发明专利8件、实用新型专利1件,其中转让3件。担任多个国际期刊编委以及十多个国际期刊审稿人。

曾获荣誉:

2016-2017年度太阳成集团优秀共产党员称号 

2017年度山西省优秀硕士学位论文指导教师

2018年山西省“三晋英才”青年优秀人才

2021年度山西省优秀硕士学位论文指导教师

2022年度山西省优秀硕士学位论文指导教师

2023年度太阳成集团优秀青年教师

2023年度山西省昆虫学会优秀科技工作者

第八届“互联网+”大学生创新创业大赛优秀指导教师

发表的代表性研究论文(标#为共同第一作者,标*为通讯作者)

1. Xiaoming Zhao#*, Qian Ma#, Ti Shao#, Pan Jia#, Zhaochen Wu, Caiyan Huo, Yuxin Wang, Weimin Liu, Zhangwu Zhao, Chen-Zhu Wang, Sheng Li*, and Jianzhen Zhang*. The Tra/Dsx-JHBP axis controls female-specific gene expression and oviposition in locusts. PLoS Biology. 2025, 23(8): e3003321.

2. Weimin Liu#, Xiuli Yang#, Yuxin Wang, Jianzhen Zhang, Xiaoming Zhao*. The LIM domain protein LmFHL2 is required for nymph-adult metamorphosis of Locusta migratoria. Pesticide Biochemistry and Physiology. 2025, 214, 106598.

3. Weimin Liu, Yiyan Zhao, Xiaoming Zhao*, Hongfang Guo, Yang Yang, Bernard Moussian*, Jianzhen Zhang*. The pore canal protein snsl is required for cuticular lipids transport and cuticle barrier function in the migratory locust, Locusta migratoria. Insect Biochemistry and Molecular Biology. 2025, 181, 104314.

4. Caiyan Huo, Sikai Liu, Babar Hussain Chang, Zhuowang Cheng, Yanan Zhang, Weimin Liu, Jianzhen Zhang, Xiaoming Zhao*. Zinc finger protein Rotund is essential for wings and ovarian development by regulating lipid homeostasis in Locusta migratoria. International Journal of Biological Macromolecules. 2025, 286, 138448.

5. Yichao Zhang#, Hongjing Li#, Xiaoman Liu#, Hongli Li, Qiuyan Lan, Haihua Wu, Yanli Wang, Jianzhen Zhang and Xiaoming Zhao*. Nuclear Receptor FTZ-F1 controls locust molt by regulating the molting process of Locusta migratoria. Insects. 2024, 15, 237.

6. Jing Zhang, Zhaochen Wu, Shuo Li, He Huang, Suning Liu, Weimin Liu, Xiaoming Zhao*, Jianzhen Zhang*. Development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis. Journal of Integrative Agriculture. 2024, 23(4): 1285–1299.

7. Yiyan Zhao, Weimin Liu, Xiaoming Zhao*, Zhitao Yu, Hongfang Guo, Yang Yang, Hans Merzendorfer, Kun Yan Zhu, Jianzhen Zhang*. Low-density lipoprotein receptor-related protein 2 (LRP2) is required for lipid export in the midgut of the migratory locust, Locusta migratoria. Journal of Integrative Agriculture. 2024, 23(5): 1618–1633.

8. Zhao, XM. #*, Su, YZ. #, Shao, T., Fan, ZY., Cao, LL., Liu, WM., Zhang, JZ*. Cuticle protein gene LmCP8 is involved in the structural development of the ovipositor in the migratory locust Locusta migratoria. Insect Molecular Biology. 2022. 31(6):747-759.

9. Zhao, XM. #*, Shao, T.#, Su, YZ., Zhang, J., Gou, X., Liu, WM., Zhang, JZ*. Cuticle Protein LmACP19 Is Required for the Stability of Epidermal Cells in Wing Development and Morphogenesis of Locusta migratoria. Int. J. Mol. Sci. 2022, 23, 3106.

10. Zhao XM#*, Niu N#, Yang JP, Liu WM, Zhang JZ*. LmIntegrinβ‐PS is required for wing morphogenesis and development in Locusta migratoria. Insect Science. 2021, 28, 705-717.

11. Zhao XM#*, Yang JP#, Gou X, Liu WM, Zhang JZ*. Cuticular protein gene LmACP8 is involved in the wing morphogenesis in the migratory locust, Locusta migratoria. Journal of Integrative Agriculture. 2021, 20(6): 1596-1606.

12. Zhao XM, Zhang J, Yang JP, Niu N, Zhang JZ, Yang Q*. Mucin family genes are essential for the growth and development of the migratory locust, Locusta migratoria. Insect Biochemistry and Molecular Biology. 2020, 123, 103404.

13. Zhao XM#, Yang Y#, Niu N, Zhao YY, Liu WM, Ma EB, Moussian B, Zhang JZ*. The fatty acid elongase gene LmELO7 is required for hydrocarbon biosynthesis and cuticle permeability in the migratory locust, Locusta migratoria. Journal of Insect Physiology. 2020, 123, 104052.

14. Zhao XM#*, Zhang J#, Niu N, Weimin Liu, Jianzhen Zhang*. BTB domain-containing protein 6 is involved in the development of locust wings during the nymph to adult transition. International Journal of Biological Macromolecules. 2020, 150, 965–973.

15. Zhao XM#, Xin Gou#, Weimin Liu, Enbo Ma, Bernard Moussian, Sheng Li, KunYan Zhu, Jianzhen Zhang*. The wing-specific cuticular protein LmACP7 is essential for normal wing morphogenesis in the migratory locust. Insect Biochemistry and Molecular Biology. 2019, 112, 103206.

16. Zhao XM#, Jian P#, Zhang J, Yang Y, Liu WM, Zhang JZ*. Structural glycoprotein LmAbd-9 is required for the formation of the endocuticle during locust molting. International Journal of Biological Macromolecules. 2019, 125: 588–595.

17. Zhao XM#, Qin ZY#, Zhang J, Yang Y, Jia P, Yang Q, Ma EB, Zhang JZ*. Nuclear receptor hormone receptor 39 is required for locust moulting by regulating the chitinase and carboxypeptidase genes. Insect Molecular Biology. 2019, 28(4), 537–549.

18. Zhao XM#, Qin ZY#, Liu WM, Liu XJ, Moussian B, Ma EB, Li S, Zhang JZ*. Nuclear receptor HR3 controls locust molt by regulating chitin synthesis and degradation genes of Locusta migratoria. Insect Biochemistry and Molecular Biology. 2018, 92: 1-11.

19. Zhao XM, Chu XH, Liu Y, Liu QN*, Jiang SH, Zhang DZ, Tang BP, Zhou CL, Dai LS*. A myeloid differentiation factor 88 gene from yellow catfish Pelteobagrus fulvidraco and its molecular characterization in response to polyriboinosinic polyribocytidylic acid and lipopolysaccharide challenge. International Journal of Biological Macromolecules. 2018, 120: 1080-1086.

20. Zhao XM#, Gou X#, Qin ZY, Li DQ, Wang Y, Ma EB, Li S, Zhang JZ*. Identification and expression of cuticular protein genes based on Locusta migratoria transcriptome. Scientific Reports. 2017. 7: 45462.

21. Zhao XM#, Liu C#, Jiang LJ, Li QY, Zhou MT, Cheng TC, Mita K, Xia QY*. Juvenile hormone-Transcription Factor Bmdimm-Fibroin H-chain Pathway involves in the regulation of the synthesis of the silk proteins in silkworm, Bombyx mori. Journal of Biological Chemistry. 2015, 290: 972-986.

22. Zhao XM, Chun Liu, Qiong-Yan Li, Wen-Bo Hu, Meng-Ting Zhou, Hong-Yi Nie, Yin-Xia Zhang, Zhang-Chuan Peng, Ping Zhao, Qing-You Xia. Basic Helix-Loop-Helix Transcription Factor Bmsage Is Involved in Regulation of fibroin H-chain Gene via Interaction with SGF1 in Bombyx mori. PLoS ONE, 2014, 9(4): e94091.

23. Zhao Y#, Liu W#, Zhao XM#, Yu Z, Guo H, Yang Y, Zhang J, Moussian B and Zhang JZ*. Apolipophorin-II/I Contributes to Cuticular Hydrocarbon Transport and Cuticle Barrier Construction in Locusta migratoria. Front. Physiol. 2020, 11:790.

24. Yang Y#, Zhao XM#*, Niu N#, Zhao YY, Liu WM, Moussian B, Zhang JZ*. Two fatty acid synthase genes from the integument contribute to cuticular hydrocarbon biosynthesis and cuticle permeability in Locusta migratoria. Insect Molecular Biology. 2020, 29, 555-568.

25. Min Liu, Li Liu, Muhammad Nadeem Abbas, Saima Kausar, Junwei Zhang, Zhize Ye, Xingyi Qian, Zhao XM*, Shenghui Chu, Lishang Dai∗. Involvement of Gamma interferon inducible lysosomal thiol reductase in the innate immune responses of red swamp crayfish, Procambarus clarkia. Developmental and Comparative Immunology, 2019, 99: 103405.

26. Bian D, Zhao XM*, Chen L, Tian J, Liu Q*. Molecular cloning and expression analysis of the highly conserved eukaryotic translation initiation factor 5A (eIF-5A) from Antheraea pernyi. Entomological Research, 2018, 48 (1). 11–17.

27. Liu Y, Xin ZZ, Zhu XY, Zhao XM*, Wang Y, Tang BP, Zhang HB, Zhang DZ, Zhou CL, Liu QN*. The complete mitochondrial genome of Euproctis similis (Lepidoptera: Noctuoidea: Erebidae) and phylogenetic analysis. International Journal of Biological Macromolecules, 2017, 105(1): 219-227.

28. Liu QN, Xin ZZ, Zhu XY, Chai XY, Zhao XM*, Zhou CL, Tang BP*. A transfer RNA gene rearrangement in the lepidopteran mitochondrial genome. Biochemical and Biophysical Research Communications, 2017, 489(2):149-154.

荣获奖励

赵小明、杨青、刘卫敏、刘晓健. 重大农业害虫几丁质结合蛋白功能及调控机制.山西省科学技术奖(自然科学类)二等奖(2024-Z-2-020),2024年。

参编著作

1. Zhao XM, Zhang JZ and Zhu KY. Extracellular Sugar-Based Biopolymers Matrices. Editor: Ephraim Cohen and Hans Merzendorfer. Springer 2019, Chapter 1: 3-57.

2. Liu, W., Liu, X., Zhao, X., Zhu, K.Y., Zhang, J. (2025). RNAi in the Migratory Locust: Functional Studies of the Genes in the Formation and Development of Cuticle. In: Smagghe, G., Palli, S.R., Swevers, L. (eds) RNA interference in Agriculture: Basic Science to Applications. Springer, Cham. pp 249–268. https://doi.org/10.1007/978-3-031-81549-2_11

3. 昆虫表皮发育与害虫防治(张建珍和朱坤炎主编). 赵小明, 第三章:昆虫表皮蛋白. 科学出版社. 2024.2第一版, pp38-55.

授权(转让)发明专利

1. 赵小明,杨洋,张建珍,刘卫敏,马恩波.一种飞蝗脂肪酸合成酶基因LmFAS2的dsRNA及其制备方法和应用,2020-08-04,中国,ZL201910414236.2.(已转让)

2. 赵小明,张建珍.一种飞蝗脂肪酸合成酶基因LmFAS的dsRNA及制备方法和应用,2022-03-18,中国,ZL202010245022.X.(已转让)

3. 张建珍,张睿,赵小明,刘晓健,马恩波.飞蝗Knickkopf 3-5`基因dsRNA在害虫防治中的应用,2022-05-31,中国,ZL201811562504.7(转让)

4. 杨青,赵小明.飞蝗粘蛋白Mucin17、其编码基因及其应用,2020-06-12,中国,ZL201910136232.2.

5. 张建珍,杨洋,赵小明,刘卫敏,马恩波.一种飞蝗脂肪酸合成酶基因LmFAS3的dsRNA及其制备方法和应用,2020-09-29,中国,ZL201910414226.9.

6. 张建珍,杨洋,赵小明,刘卫敏,马恩波.一种飞蝗脂肪酸延伸酶基因LmElo的dsRNA及其制备方法和应用,2020-09-29,中国,ZL201910411773.1.

7. 刘卫敏,赵艺妍,赵小明,张建珍,马恩波.飞蝗孔道形成相关基因Lmsnar及其dsRNA在飞蝗防治中的应用,2022-05-31,中国,ZL201910282608.0.

8. 张建珍,赵艺妍,赵小明,刘卫敏,马恩波.飞蝗低密度脂蛋白受体相关基因2 LmLRP2及其dsRNA在飞蝗防治中的应用,2022-05-31,中国,ZL201910282589.1.

主持或参加科研项目

1. 国家自然科学基金面上项目,飞蝗腹部节间膜延展性的形成及调控机制研究(32470507),2025-01至2028-12,在研,主持;

2. 科技部“十四五”国家重点研发计划项目“新机制农药分子靶标的发现及应用”(2022YFD1700200),“害虫特有生物合成途径中关键膜蛋白及其三维结构”子课题,2022-11至2026-12,在研,主持;

3. 山西省基础研究计划面上基金项目,化学感受蛋白LmCSP9在飞蝗产卵基质选择行为中的作用及机制研究(202403021211033),2024-07至2027-07,在研,主持;

4. 国家自然科学基金面上项目,表皮蛋白在飞蝗节间膜延展性能及产卵行为中的功能研究(31970469),2020-01至2023-12,已结题,主持;

5. 国家自然科学基金青年项目,飞蝗翅特异表皮蛋白基因LmACP19和LmACP7差异表达调控机制(31702067),2018-01至2020-12,已结题,主持;

6. 国家自然科学基金项目,飞蝗翅特异表皮蛋白基因LmACP7功能及转录调控机制研究(31640075),2017-01至2017-12,已结题,主持;

7. 中国博士后科学基金面上项目(一等资助),昆虫表皮几丁质合酶和几丁质酶基因精细调控机制研究(2019M650040),2019-05至2020-03,已结题,主持;

8. 山西省基础研究计划青年基金项目,飞蝗翅特异表皮蛋白基因功能解析及其调控机制研究(201601D021102),2016-07至2018-12,已结题,主持;

9. 山西省高等学校科技创新项目,表皮蛋白Abd-6对昆虫节间膜延展性能的影响机制研究(2019L0033),2019-07至2021-09,已结题,主持;

10. 国家自然科学基金中德国际合作项目,表皮脂类形成及对昆虫生态适应性的影响机制研究(31761133021),2018-01至2020-12,已结题,参加;

11. 国家自然科学基金项目,蜕皮激素调控飞蝗PGRPs介导的免疫反应机制(31501631),2016-01至2018-12,已结题,参加;

12. 国家重点研发计划骨干课题,飞蝗RNAi靶基因筛选及干扰机制研究(2017YFD0200904),2017-01至2021-12,已结题,参加。

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