王琛柱

   职称：教授

   研究方向:（1）信息化学与合成生物学

                  （2）植物与昆虫的相互作用

                  （3）昆虫的嗅觉和味觉

    通讯地址：chenzhuwang@sxu.edu.cn

王琛柱，男，博士生导师，国家杰出青年科学基金获得者。2024年11月入职suncitygroup太阳集团，任suncitygroup太阳集团学术院长。兼任中国昆虫学会副理事长，Pest Management Science、Arthropod-Plant Interactions、应用昆虫学报副主编，Journal of Comparative Physiology A顾问委员，BMC Ecology and Evolution、Insect Science、Entomologia Experimentalis et Applicata、Archives of Insect Biochemistry and Physiology、昆虫学报、植物保护学报编委。

王琛柱于1985年在山西农业大学获得学士学位，于1988年和1991年在北京农业大学（现名中国农业大学）分别获得硕士和博士学位。此后，进入中国科学院动物研究所做博士后研究。他于1997年晋升为中国科学院动物研究所研究员。他还作为中国科学院大学的特聘教授，长期讲授《进化生态学》、《动物与植物的相互作用》等课程，曾获中国科学院大学魏桥国科校长奖教金。曾在美国University of Arizona、荷兰Wageningen University、英国University of Cambridge做访问学者或进行合作研究。

王琛柱教授主要从事次生物质介导的植物与昆虫相互作用和昆虫信息素通信的研究。他长期聚焦研究我国重要农业害虫棉铃虫与烟青虫的性信息素通信和寄主植物选择机理，首次成功地对这两个近缘种进行种间杂交，系统阐明了雌性性信息素的生物合成路径及其遗传基础，深入揭示了雄性感受性信息素的分子基础和神经编码机制；鉴定了棉铃虫感受蔗糖、肌醇、香豆素的味觉受体，发现烟青虫的产卵器具有嗅觉功能。此外，还发现棉铃虫齿唇姬蜂的性信息素并首次鉴定了其受体，发现了小菜蛾感受植物激素芸苔素内酯的味觉受体、菜粉蝶感受两种芥子油苷的味觉受体。发表论文200余篇，主编著作《植物与昆虫的相互作用》，翻译著作《昆虫》。目前，他领导的实验室综合利用合成生物学、分子生物学、细胞生物学、电生理学、神经生物学、行为学、化学方法和技术，研究（1）芥子油苷介导的十字花科植物与昆虫的相互作用机制，（2）昆虫的嗅觉和味觉受体神经元及相关受体的结构与功能，为可持续治理害虫提供新思路、新方法和新途径。

代表性研究成果：

2025年发表论文

1. 王琛柱, 莫宝童和张建珍 (2025) 在合成生物学时代利用信息化学物质改进害虫防治. 新兴科学和技术趋势 4: 1-12. doi: 10.12405/j.issn.2097-1486.2025.01.001.

2. 莫宝童和王琛柱 (2025) 昆虫化学感受研究的历史及在我国的新进展. 应用昆虫学报62: 1473-1495. doi: 10.7679/j.issn.2095-1353.2025.125.

3. Gong X-L, Guo H, Yang K, Li G-C, Li Z-L, Huang L-Q & Wang C-Z (2025) A highly expressed pheromone receptor in the male and female antennae of Helicoverpa armigera is tuned to plant volatiles. Journal of Agricultural and Food Chemistry 73: 29409-29420. doi: 10.1021/acs.jafc.5c07262.

4. Guo H & Wang C-Z (2025) Harnessing semiochemicals for parasitoid-based biological control: from laboratory identification to field applications. Crop Health 3: 21. doi: 10.1007/s44297-025-00061-4.

5. Zhao X, Ma Q, Shao T, Jia P, Wu Z, Huo C, Wang Y, Liu W, Zhao Z, Wang C-Z, Li S & Zhang J (2025) The Tra/Dsx-JHBP axis controls female-specific gene expression and oviposition in locusts. PLoS Biology 23: e3003321. doi: 10.1371/journal.pbio.3003321.

6. Tan Y-S, Mo B-T, Li G-C, Guo Y-R, Zhang J-Z & Wang C-Z (2025) HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae. PLoS Genetics 21: e1011744. doi: 10.1371/journal.pgen.1011744.

7. Fan X-B, Cao L-L, Xu X, Yang J, Huang L-Q & Wang C-Z (2025) A token stimulus receptor tuned to gluconapin in the cabbage white butterfly. Journal of Agricultural and Food Chemistry 73: 21022-21034. doi: 10.1021/acs.jafc.5c05474.

8. Shahid S, Li G-C, Guo H, Yan X, Zhang S-C, Cao L-L, Gong X-L & Wang C-Z (2025) Deorphanization of pheromone receptors and discovery of a novel agonist for sex pheromone communication in diamondback moths. Journal of Agricultural and Food Chemistry 73: 5816−5828. doi: 10.1021/acs.jafc.4c11699.

9. Wang P-C, Niu Y-H, Chen Y, Zhang S-S, Wu F-M, Yang M-K, Huang L-Q, Li C, Xu C-Q & Wang C-Z (2025) Regulation of feeding behaviors by key sugar and bitter gustatory receptors in Helicoverpa armigera. Pest Management Science 81: 6241-6254. doi: https://doi.org/10.1002/ps.8968.

10. Wang W, Zhong Y, Tan R, Wang M, Liu J, Wang D, Wang H, Li Y, Li G, Yang J, Wang P, Wu J, Zhang J, Wang C-Z, Shi H, Ma M, Yu Y & Zhang Y-F (2025) A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice. Proceedings of National Academy of Sciences of the United States of America 122: e2514847122. doi: 10.1073/pnas.2514847122.

11. Yang L, Wang X-Z, Wang C-Z, Wang D-H, Wang Z-S & Zhang X-Y (2025) Time-restricted feeding modulates gene expression related with rhythm and inflammation in Mongolian gerbils. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 287: 110038. doi: https://doi.org/10.1016/j.cbpc.2024.110038.

12. Yang X-Z, Wang C-Z, Wang D-H & Zhang X-Y (2025) Specific adaptive mechanisms in water-sodium regulation in a desert rodent fed with salty diets. Comprehensive Physiology 15: e70015. doi: https://doi.org/10.1002/cph4.70015.

13. Yang J, Lu Q, Shi Y-Z, Sun L-Y, Mo B-T, Li G-C, Wang C-Z, Wang Y, Hu J, Jia D & Ma R (2025) Larval taste perception to fucose and its implications via an altered gut microbiota in the fall armyworm Spodoptera frugiperda. Pest Management Science. doi: https://doi.org/10.1002/ps.70286.

之前部分论著

1. Zhang S-S, Wang P-C, Ning C, Yang K, Li G-C, Cao L-L, Huang L-Q & Wang C-Z (2024) Sucrose taste receptors differ in larval and adult stages of a moth. eLife 12: RP91711.

2. Wang C-Z & van Loon JJA (2024) Chemosensory detection of glucosinolates as token stimuli for specialist insects on brassicaceous plants: discovery and impact. Journal of Comparative Physiology A 210: 243-248.

3. 王琛柱, 娄永根 (2023)《植物与昆虫的相互作用》 科学出版社, 北京。

4. Mo B-T, Guo H, Li G-C, Cao LL, Gong X-L, Huang L-Q & Wang C-Z (2023) Discovery of insect attractants based on the functional analyses of female-biased odorant receptors and their orthologs in two closely related species. Journal Agricultural and Food Chemistry 71: 19408-19421.

5. Shang J, Tang G, Yang J, Lu M, Wang C-Z & Wang C* (2023) Sensing of a spore surface protein by a Drosophila chemosensory protein induces behavioral defense against fungal parasitic infections. Current Biology 33: 276-286.

6. Guo H, Mo B-T, Li G-C, Li Z-L, Huang L-Q, Sun Y-L, Dong J-F, Smith DP & Wang C-Z (2022) Sex pheromone communication in an insect parasitoid, Campoletis chlorideae Uchida. Proceedings of National Academy of Sciences of the United States of America 119: e2215442119.

7. Chen Y, Wang P-C, Zhang S-S, Yang J, Li G-C, Huang L-Q & Wang C-Z (2022) Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera. PLoS Genetics 18: e1010455.

8. Fan X-B, Mo B-T, Li G-C, Huang L-Q, Guo H, Gong X-L & Wang C-Z (2022) Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera. BMC Biology 20: 214.

9. Guo H, Gong X-L, Li G-C, Mo B-T, Jiang N-J, Huang L-Q & Wang C-Z (2022) Functional analysis of pheromone receptor repertoire in the fall armyworm, Spodoptera frugiperda. Pest Management Science 78: 2052-2064.

10. Guo H, Huang L-Q, Gong X-L & Wang C-Z (2022) Comparison of functions of pheromone receptor repertoires in Helicoverpa armigera and Helicoverpa assulta using a Drosophila expression system. Insect Biochemistry and Molecular Biology 141: 103702.

11. Guo H, Guo P-P, Sun Y-L, Huang L-Q & Wang C-Z (2021) Contribution of odorant binding proteins to olfactory detection of (Z)-11-hexadecenal in Helicoverpa armigera. Insect Biochemistry and Molecular Biology 131: 103554.

12. Yang J, Guo H, Jiang N-J, Tang R, Li G-C, Huang L-Q, van Loon JJA & Wang C-Z (2021) Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae. PLoS Genetics 17: e1009527.

13. Yang K, Gong X-L, Li G-C, Huang L-Q, Ning C & Wang C-Z (2020) A gustatory receptor tuned to the steroid plant hormone brassinolide in Plutella xylostella (Lepidoptera: Plutellidae). eLife 9: e64114.

14. Li R-T, Huang L-Q, Dong J-F & Wang C-Z (2020) A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles. eLife 9: e53706.

15. Liu X-L, Zhang J, Yan Q, Miao C-L, Han W-K, Hou W, Yang K, Hansson BS, Peng Y-C, Guo J-M, Xu H, Wang C-Z, Dong S-L & Knaden M (2020) The Molecular basis of host selection in a crucifer-specialized moth. Current Biology. 30: 4476-4482.

16. Tang R, Jiang N-J, Ning C, Li G-C, Huang L-Q & Wang C-Z (2020) The olfactory reception of acetic acid and ionotropic receptors in the Oriental armyworm, Mythimna separata Walker. Insect Biochemistry and Molecular Biology 118: 103312.

17. Jiang N-J, Tang R, Guo H, Ning C, Li J-C, Wu H, Huang L-Q & Wang C-Z (2020) Olfactory coding of intra- and interspecific pheromonal messages by the male Mythimna separata in North China. Insect Biochemistry and Molecular Biology 125: 103439.

18. Jiang N-J, Tang R, Wu H, Xu M, Ning C, Huang L-Q & Wang C-Z (2019) Dissecting sex pheromone communication of Mythimna separata (Walker) in North China from receptor molecules and antennal lobes to behavior. Insect Biochemistry and Molecular Biology 111: 103176.

19. Wu H, Li R-T, Dong J-F, Jiang N-J, Huang L-Q & Wang C-Z (2019) An odorant receptor and glomerulus responding to farnesene in Helicoverpa assulta (Lepidoptera: Noctuidae). Insect Biochemistry and Molecular Biology 115: 103106.

20. Zhang Z-J, Zhang S-S, Niu B-L, Ji D-F, Liu X-J, Li M-W, Bai H, Palli SR, Wang C-Z & Tan A-J (2019) A determining factor for insect feeding preference in the silkworm, Bombyx mori. PLoS Biology 17: e3000162.

21. Chen C-Y, Liu Y-Q, Song W-M, Chen D-Y, Chen F-Y, Chen X-Y, Chen Z-W, Ge S-X, Wang C-Z, Zhan S, Chen X-Y & Mao Y-B (2019) An effector from cotton bollworm oral secretion impairs host plant defense signaling. Proceedings of National Academy of Sciences of the United States of America 116: 14331-14338.

22. Yang K, Huang L-Q, Ning C & Wang C-Z (2017) Two single-point mutations shift the ligand selectivity of a pheromone receptor between two closely related moth species. eLife 6: e29100.

23. Li R-T, Ning C, Huang L-Q, Dong J-F, Li X & Wang C-Z (2017) Expressional divergences of two desaturase genes determine the opposite ratios of two sex pheromone components in Helicoverpa armigera and Helicoverpa assulta. Insect Biochemistry and Molecular Biology 90: 90-100.

24. Di C, Ning C, Huang L-Q & Wang C-Z (2017) Design of larval chemical attractants based on odorant response spectra of odorant receptors in the cotton bollworm. Insect Biochemistry and Molecular Biology 84: 48-62.

25. Ning C, Yang K, Xu M, Huang L-Q & Wang C-Z (2016) Functional validation of the carbon dioxide receptor in labial palps of Helicoverpa armigera moths. Insect Biochemistry and Molecular Biology 73: 12-19.

26. Jiang X-J, Ning C, Guo H, Jia Y-Y, Huang L-Q, Qu M-J & Wang C-Z (2015) A gustatory receptor tuned to d-fructose in antennal sensilla chaetica of Helicoverpa armigera. Insect Biochemistry and Molecular Biology 60: 39-46.

27. Liu Y-L, Guo H, Huang L-Q, Pelosi P & Wang C-Z (2014) Unique function of a chemosensory protein in the proboscis of two Helicoverpa species. Journal of Experimental Biology 217: 1821-1826. doi:10.1242/jeb.102020.

28. Jiang XJ, Guo H, Di C, Yu S, Zhu L, Huang LQ & Wang CZ (2014) Sequence similarity and functional comparisons of pheromone receptor orthologs in two closely related Helicoverpa species. Insect Biochemistry and Molecular Biology 48: 63-74.

29. Guo H, Huang L-Q, Pelosi P & Wang C-Z (2012) Three pheromone-binding proteins help segregation between two Helicoverpa species utilizing the same pheromone components. Insect Biochemistry and Molecular Biology 42: 708-716.

30. Zhang Y-F, van Loon JJ & Wang C-Z (2010) Tarsal taste neuron activity and proboscis extension reflex in response to sugars and amino acids in Helicoverpa armigera (Hubner). Journal of Experimental Biology 213: 2889-2895.

近期主持NSFC项目

1. 十字花科植物专食性昆虫搜寻寄主的嗅觉感受机制：菜粉蝶与小菜蛾的比较研究，国家自然科学基金面上项目（32372541），2024年1月至2027年12月，50万元

2. 十字花科作物专食性害虫对芥子油苷成瘾的味觉分子机制及其演化，国家自然科学基金重点项目（32130090），2022年1月至2026年12月，286万元

3. 铃夜蛾属二近缘种的产卵选择行为及其嗅觉编码机制，国家自然科学基金重点项目（31830088），2019年1月至2023年12月，290万元